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Beijing Region (3pter-D3S3397) of the Human Genome: Complete sequence and analysis
The goal of the Human Genome Project (HGP) is to determine a complete and high-quality sequence of the human genome. China, as one of the six member states, takes a region between 3pter and D3S3397 of the human chromosome 3 as its share of this historic project, referred as "Beijing Region". The complete sequence of this region comprises of 17.4 megabasepairs (Mb) with an average GC content of 42% and an average recombination rate of 2.14 cM/Mb. Within Beijing Region, 122 known and 20 novel genes are identified, as well as 42607 single nucleotide polymorphisms (SNPs). Comprehensive analyses also reveal: (i) gene density and GC-content of Beijing Region are in agreement with human cytogenetic maps, i.e. G-minus bands are GC-rich and of a high gene density, whereas G-plus bands are GC-poor and of a relatively low gene density; (ii) the average recombination rate within Beijing Region is relatively high compared with other regions of chromosome 3, with the highest recombination rate of 6.06 cM/Mb in the subtelomeric area; (iii) it is most likely that a large gene, associated with the mammary gland, may reside in the 1.1 Mb gene-poor area near the telomere; (iv) many disease-related genes are genetically mapped to Beijing Region, including those associated with cancers and metabolic syndromes. All make Beijing Region an important target for in-depth molecular investigations with a purpose of medical applications.
作 者： The Chinese Human Genome Sequencing Consortium 作者單位： Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China /James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008, China;Chinese National Human Genome Center at Shanghai (CHGC), Shanghai 201203, China;Chinese National Human Genome Center, Beijing (CHGB), Beijing 100176, China 刊 名： 中國(guó)科學(xué)C輯（英文版） SCI 英文刊名： SCIENCE IN CHINA (LIFE SCIENCES) 年，卷(期)： 2005 48(4) 分類(lèi)號(hào)： Q3 關(guān)鍵詞： Human Genome Project (HGP) "Beijing Region" complete sequence genome landscape sequence annotation【Beijing Region (3pter-D3S3397) of th】相關(guān)文章：
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